Gene-Editing Therapy Saves Lives Of Two Baby Girls With Leukemia

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The world may be in a dark place right now, but science is providing plenty of light to fight off the shadows. Take the case of two babies that have just been rescued from previously incurable forms of leukemia thanks to gene-editing therapy, their lives will no longer be cut short.

Writing in the journal Science Translational Medicine, a European team of researchers report that two girls have remained cancer-free 18 and 12 months after being given a novel treatment. In this case, it involved genetically engineering white blood cells to give them the ability to effectively target cancerous cells.

The teams paper notes that molecular remissions were achieved within 28 days in both infants, an incredibly short space of time. At present, the two younglings have shown no signs of the acute lymphocytic leukemia they were once riddled with.

Without the hard work of the team at both Londons Great Ormond Street Hospital and Cellectis, a French Biotech firm, these extremely young children wouldnt be around today.

This technique has been used before by various drug companies, but the engineered white blood cells have been extracted from patients that are themselves undergoing treatment. In this case, the killer cells were taken from healthy donors and then engineered to attack the cancer cells in the young patients.

Although this could have caused the two girls immune systems to negatively react to and destroy the alien white blood cells injected into their bodies, this wasnt the case at least initially.

The team did note that the first young patient did indeed have a bad immune reaction to the treatment two months after it took place, but after a round of steroids and some bone marrow transplantation, shes now doing well.

This could be the first of many lives saved, both young and old. DONOT6_STUDIO/Shutterstock

One of the reasons this new method was tested on these babies is that extremely young children do not have many white blood cells as it is. Taking any away from them could weaken their immune system to a dangerous point.

The fact that this transference technique appears to be effective suggests that it could be a truly universal therapy, one that works on all donors regardless of age or relative immune system strength. Plenty more work is needed to confirm that this technique works on others, including older children and adults, but this trial is so far looking to be incredibly successful.

Cancer comes in hundreds of forms, each with varying ways of sneaking past our immune systems and corrupting our bodies. Although there has been an upsurge in increasingly effective and ingenious ways to treat cancers, it remains a scourge.

As this research shows, however, the tide may beturning.

[H/T: Reuters]

Read more: http://www.iflscience.com/health-and-medicine/geneediting-therapy-saves-lives-baby-girls-leukemia/

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Trump can learn an important lesson from Mr. Rogers

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If you were a child in America anytime between the ’60s and ’90s, there’s a certain man in a red sweater who was probably there for you.

Fred Rogers, better known as the one and only Mr. Rogers, spent over four decades hosting educational TV programs for kids. In 1969, the same year PBS was founded, he appeared before the U.S. Senate Commerce Committee and gave a moving speech on what publicly funded TV programs could offer.

Of course, all this talk about public TV feels more important than ever, given the Trump Administration’s plans to eliminate the Corporation for Public Broadcasting (which funds PBS, where Sesame Street still airs, despite the show being sold to HBO) as well as three other independent agencies for culture and the arts.

In Mr. Roger’s speech from the late 1960s, he touches on the importance of his own programs, which deal with the “inner dramas” of childhood in a way that can’t be done with privately funded cartoons airing elsewhere, he said.

“We don’t need to bop someone over the head to make drama on the screen,” he told the committee. “We deal with such things as getting a haircut or the feelings about brothers and sisters or the kind of anger that arises in simple family situations. And we speak to it constructively.”

The beloved TV host seems ahead of his time, explaining exactly why the physical health of children isn’t the only thing to be worried about.

“I feel that if we, in public television, can only make it clear that feelings are mentionable and manageable,” he said. “We will have done a great service for mental health.”

The song he later recites will literally melt your heart. We still miss you, Mr. Rogers.

Read more: http://mashable.com/2017/03/16/mr-rogers-defends-public-tv-trump/

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Study Reveals That Women With Big Butts Are Smarter and Healthier

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Via: Elite Daily

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Alleged Florida school shooter Nikolas Cruz was reported to FBI, cops, school — but warning signs missed

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Attorney General Jeff Sessions on Friday ordered an “immediate review” after it emerged that the FBI had not acted on a recent tip that Florida school shooting suspect Nikolas Cruz wanted to “kill people” and there was the “potential of him conducting a school shooting.”

In a statement, the FBI admitted to receiving a call on Jan. 5 from a person close to Cruz who contacted the FBI through its Public Access Line (PAL) tipline to express concerns about his erratic behavior and disturbing social media posts.

Cruz, 19, opened fire at Marjory Stoneman Douglas High School on Wednesday, killing 17 people. He has reportedly confessed. 

“Under established protocols, the information provided by the caller should have been assessed as a potential threat to life,” the statement said. “We have determined that these protocols were not followed for the information received by the PAL on Jan. 5.”

“It is now clear that the warning signs were there and tips to the FBI were missed,” Sessions said in a Friday afternoon statement. “We see the tragic consequences of those failures.”

“The FBI in conjunction with our state and local partners must act flawlessly to prevent all attacks,” Sessions continued. “This is imperative, and we must do better. I have ordered the deputy attorney general to conduct an immediate review of our process here at the Department of Justice and FBI to ensure that we reach the highest level of prompt and effective response to indications of potential violence that come to us.”

The FBI concluded that the caller’s information was not forwarded to the Miami FBI field office, and that “no further investigation was conducted at the time.” FBI Director Christopher Wray said the bureau would review what had happened.

“We are still investigating the facts.  I am committed to getting to the bottom of what happened in this particular matter, as well as reviewing our processes for responding to information that we receive from the public,” Wray said in the statement. “It’s up to all Americans to be vigilant, and when members of the public contact us with concerns, we must act properly and quickly.”

He continued: “We have spoken with victims and families, and deeply regret the additional pain this causes all those affected by this horrific tragedy.  All of the men and women of the FBI are dedicated to keeping the American people safe, and are relentlessly committed to improving all that we do and how we do it.”

Cruz had dozens of run-ins with law enforcement prior to Wednesday’s shooting at Marjory Stoneman Douglas High dating back to 2010 — with one report saying deputies responded to his home more than 35 times in just six years.

Broward County deputies received at least 36 emergency 911 calls from 80th Terrace St. in Parkland – the suburban address where the teenager lived with his younger brother, Zachary, and their adoptive mother, Lynda, BuzzFeed reported.

The calls – dating as far back as 2010 and continuing until November 2016 – shed a light on two erratic and violent boys who repeatedly “threw items,” were “out of control” and fought with their mother and each other on an apparently regular basis.

“He is a deeply troubled young man; a child that has endured significant loss,” Gordon Weekes, chief assistant for Broward County’s public defender’s office, told reporters Thursday. “He fell between the cracks and we have to try to save him now.”

NIKOLAS CRUZ WAS LIVING WITH HS STUDENT IN MONTHS LEADING UP TO MASSACRE, ATTORNEY SAYS

Despite the repeated calls to authorities, Cruz was never arrested – and was basically cleared as being “no threat to anyone or himself,” as one therapist said in a police report from Sept. 28, 2016.

In that particular call, the sheriff’s office said Nikolas and his mother were fighting over paperwork needed for him to get an ID card.

In their report, deputies detailed how the teen had been harming himself and had talked about buying a gun.

“He had been cutting his arms, his mother said, to get attention, as he learned it from an ex-girlfriend,” deputies said. “He has mentioned in the past that he would like to purchase a firearm.”

The therapist on scene, Jared Bienenfeld with Henderson Mental Health, and the deputies concluded there were “no signs of mental illness or criminal activity.”

And much like the calls before – which were placed due to reasons ranging from the brothers reportedly beating each other to Cruz, at the age of 12, threatening his mother and calling her a “useless b****” – law enforcement left without taking any further action.

A public information officer with the sheriff’s office could not verify the report to Fox News early Friday. The sheriff’s office did not immediately respond to additional requests for comment.

Cruz wasn’t arrested until Valentine’s Day, when he allegedly walked into the high school with a gas mask, smoke grenades and multiple magazines of ammunition before firing an AR-15 at students and faculty members.

He was charged with 17 counts of premeditated murder on Thursday and is being held without bail.

In the aftermath of the attack, revelations about the teen’s alarming warning signs appeared to be repeatedly missed — despite the cop calls, a report to the FBI based on a social media posting, his former classmates expressing fear of him and a documented history of mental health issues.

TRUMP: ‘SO MANY SIGNS’ FLORIDA SHOOTING SUSPECT WAS ‘MENTALLY DISTURBED’

“I think everyone had in their minds if anybody was going to do it, it was going to be him,” Victoria Olvera, a 17-year-old junior at the school, told the Sun-Sentinel.

According to reports, Cruz and his brother both suffered from mental health issues, including ADHD and OCD, and took medication as treatment. Cruz’s lawyer said Thursday her client was “a broken human being” and the team was looking into an evaluation for autism. Nikolas had sought treatment at Henderson Mental Health Clinic and had previously attended a school for students with behavioral problems, BuzzFeed reported.

Despite these issues, Cruz was able to legally purchase the AR-15 he used in the mass shooting. Attorney Jim Lewis told the Sun-Sentinel that the teenager already owned the gun when he moved in with his friend’s family around Thanksgiving, after his mother’s November death.

“It was his gun,” Lewis said. “The family made him keep it in a locked gun cabinet in the house but he had a key.”

Trevor Hart, 16, who knew Cruz from his Spanish class at Marjory Stoneman, told the Sun-Sentinel the alleged killer seemed “a little off” and talked about shooting lizards, squirrels and frogs.

Cruz was expelled from Marjory Stoneman last year for “disciplinary problems,” with one report saying bullets were discovered in his backpack at one point.

One teacher told the Miami Herald that Cruz was banned from entering campus with a backpack.

Officials did not immediately say why Cruz was expelled.

FLORIDA HIGH SCHOOL FOOTBALL COACH WHO WAS SEEN SHIELDING STUDENTS FROM GUNFIRE DIES

An Instagram page apparently belonging to Cruz showed pictures of guns and knives. Broward County Sheriff Scott Israel said some of Cruz’s social media posts were “very, very disturbing.”

Additionally, the FBI confirmed Thursday the bureau received a tip this past September about a disturbing YouTube comment by a user named “Nikolas Cruz” that said, “I’m going to be a professional school shooter.”

Special Agent Rob Lansky, in charge of the FBI’s Miami division, said the agency investigated the comment, but said it could not identify the user who made the comment. He also said there was no connection found to South Florida.

“No other information was included in the comment which would indicate a particular time, location or the true identity of the person who posted the comment,” the FBI said in a subsequent statement.

On Thursday, Florida Sen. Marco Rubio said it was “inexcusable” that the FBI had failed to follow protocols that could have prevented Wednesday’s shooting.

“The fact that the FBI is investigating this failure is not enough. Both the House and Senate need to immediately initiate their own investigations into the FBI’s protocols for ensuring tips from the public about potential killers are followed through,” the Republican senator said in a statement.

He continued: “Lawmakers and law enforcement personnel constantly remind the public that ‘if you see something, say something.’ In this tragic case, people close to the shooter said something, and our system utterly failed the families of seventeen innocent souls.”

Also Friday: Florida Gov. Rick Scott called for Wray to resign. “We constantly promote ‘see something, say something,’ and a courageous person did just that to the FBI,” Scott said in a statement. “And the FBI failed to act. ‘See something, say something’ is an incredibly important tool and people must have confidence in the follow through from law enforcement. The FBI Director needs to resign.”

Fox News’ Matt Richardson, Ryan Gaydos, Elizabeth Zwirz, Shira Bush and The Associated Press contributed to this report.

Lucia I. Suarez Sang is a Reporter for FoxNews.com. Follow her on Twitter @luciasuarezsang

Read more: http://www.foxnews.com/us/2018/02/16/alleged-florida-school-shooter-nikolas-cruz-was-reported-to-fbi-cops-school-but-warning-signs-missed.html

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Biosensing Tattoo Changes Color When Your Blood Sugar Levels Change

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Having type 1 or 2 diabetes requires a person to always know what their blood sugar levels are. This normally takes time and can be quite invasive normally people prick their finger with a special device and place a small drop of blood on a testing strip. Others have a device implanted just under their skin that continuously measures their blood sugar levels and sends the information to an external device.

A team of researchers at Harvard and MIT have now come up with a rather curious alternative. Using a specialized ink, they have come up with a biosensing tattoo, one that will change color depending on your blood sugar levels.

Known as DermalAbyss ink currently still in the proof-of-concept stage and not available to the general public it is able to track pH levels, as well as sodium and glucose concentrations within your bloodstream. Too much glucose and the ink becomes brown. Too much sodium and it becomes green (under UV light, at least). Purples and pinks indicate a changing pH level.

The DermalAbyss ink presents a novel approach to biointerfaces in which the bodys surface is rendered as an interactive display, the team explain in a promotional video.

The dynamic ink isnt directly hooked up to your bloodstream, to be fair; its actually monitoring your interstitial fluid, a substance that surrounds the tissue cells of animals. Water, ions and small solutes including salts, sugars, fatty and amino acids and hormones are constantly making their way through this fluid across the walls of your capillaries.

At present, its only been tested on pig skin, which is very similar to our own. However, it definitely works but human trials are still required to see if its workable with patients. Are there any allergic reactions that people may have to the ink? Will the technology break down over time?

Still, its safe to say that this is a rather novel and elegant solution to a problem that hasnt really been addressed for some time. Only time will tell if it catches on. Its still invasive, of course but only at first, whereupon it then just becomes a part of your biology.

The researchers point out that the tattoo can take any shape or form you like, so each persons will be unique to them much like conventional tattoos.

We envision new participation between the biotech companies and skin professionalsin order to embrace the idea of human device symbiosis, they conclude.

[H/T: CBS News]

Read more: http://www.iflscience.com/health-and-medicine/biosensing-tattoo-changes-color-blood-sugar-levels-change/

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I Was Diagnosed With Schizophrenia At The Age Of 17, So I Started Drawing My Hallucinations To Cope With It

I have always been an ‘artist’, I just didn’t realize what that meant until my mental illness appeared. I despise the term ‘mentally ill’; it implies that who I am as a person is fundamentally corrupted and broken.

Unfortunately, as soon as I tell people what I struggle with, I feel like that’s all they see me as. They see the stigma perpetuated by the media, and the inaccurate stereotypes portrayed in Hollywood. That is precisely why I am so open about what I live with.

My name is Kate and I’m an 18-year-old artist with schizophrenia

I’ve been ‘diagnosed’ with multiple labels over the years. At the age of 17 I finally was diagnosed with schizophrenia after my parents realized my mental health was getting worse

I draw a lot of my hallucinations as drawing helps me deal with it

In my hallucinations I hear voices, sound effects, random noises, and I often see bugs, faces, and disembodied eyes

Inanimate objects will look like a Van Gogh painting: warped and swirly.

I hallucinate bugs quite often, and my depression makes me feel worthless like a fly. These bug illustrations represent my illness

This is a quote by an artist named Jory, and it was something that spoke to me.

This one crawls out of the vent in my ceiling and makes clicking noises, or I’ll see it crawl out from underneath things

This is a self-portrait. I looked in the mirror and my eyes did this thing. I painted it

I have a lot of intense emotions, and hear voices telling me to light things on fire

Here is an example of the disembodied eyes I see. They surface in a mounds or masses on my walls or floors. They warp and move.

This is Birdie, she sings to me

My self esteem is at its lowest, and I feel insignificant. I always wish I could shapeshift into a “prettier” person

What eyes sometimes look like, with more of those odd colors and circles

Organization, communication, paranoia, depression, anxiety, and managing my emotions are the biggest struggles for me

What I live with isn’t easy and it can be debilitating, but I’m not living out on the streets screaming about alien abductions. That’s not to say there aren’t people out there who are that severe – there are. However, there are also people like me who just stay at home most of the time cooped up in their room. It is a spectrum of symptoms with varying severity levels. Each person’s experience is unique.

Read more: http://www.boredpanda.com/18-year-old-schizophrenic-artist-drawing-hallucinations/

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Trump Proposes to Cut Medicare and Spend Big on Wall, Defense

President Donald Trump will propose cutting entitlement programs by $1.7 trillion, including Medicare, in a fiscal 2019 budget that seeks billions of dollars to build a border wall, improve veterans’ health care and combat opioid abuse and that is likely to be all but ignored by Congress.

The entitlement cuts over a decade are included in a White House summary of the budget obtained by Bloomberg News. The document says that the budget will propose cutting spending on Medicare, the health program for the elderly and disabled, by $237 billion but doesn’t specify other mandatory programs that would face reductions, a category that also includes Social Security, Medicaid, food stamps, welfare and agricultural subsidies.

The Medicare cut wouldn’t affect the program’s coverage or benefits, according to the document. The budget will also call for annual 2 percent cuts to non-defense domestic spending beginning “after 2019.’

At a time when the prospect of rising annual budget shortfalls has spooked financial markets, the White House said in a statement — without explanation — that its plan would cut the federal deficit by $3 trillion over 10 years and reduce debt as a percentage of gross domestic product. Yet, in a break from a longstanding Republican goal, the plan won’t balance the budget in 10 years, according to a person familiar with the proposal.

The budget, to be released later on Monday, is unlikely to gain traction on Capitol Hill. Lawmakers routinely ignore the spending requests required annually from the executive branch. And Congress passed its own spending bill on Friday, including a two-year budget deal, which the president signed into law.

According to the summary, Trump will urge an increase in defense spending to $716 billion and a 2.6 percent pay raise for troops. He will request $18 billion to build a wall on the Mexican border, the summary indicates.

The White House also seeks $200 billion for the infrastructure proposal the administration plans to unveil alongside the fiscal year 2019 budget, as well as new regulatory cuts.

“This will be a big week for Infrastructure,” Trump said in a Twitter message Monday. “After so stupidly spending $7 trillion in the Middle East, it is now time to start investing in OUR Country!”

Monday’s document will outline proposed spending reforms the administration says would, if enacted, cut deficits over the next decade — even as recently passed tax legislation and spending caps threaten to drive future annual deficits above $1 trillion.

Trump May Struggle on $1 Trillion Pledge to Fix Crumbling U.S.

“Just like every American family, the budget makes hard choices: fund what we must, cut where we can, and reduce what we borrow,” Office of Management and Budget Director Mick Mulvaney said in a statement. “It’s with respect for the hard work of the American people that we spend their tax dollars efficiently, effectively, and with accountability.”

A year ago, Trump asked lawmakers to cut $3.6 trillion in federal spending over the next ten years, and identified deep cuts to domestic spending programs. Instead, lawmakers last week passed a two-year government funding deal that would boost military and non-defense spending by $300 billion over the next two years and add more than $80 billion in disaster relief.

But administration officials argue their proposals, dead on arrival though they may be, is still an important marker of the president’s legislative priorities.

Immigration Enforcement

The plan includes a heavy emphasis on immigration enforcement. Trump is requesting $782 million to hire 2,750 new border and immigration officers, and $2.7 billion to detain people in the country illegally. Trump is also asking for $18 billion over the next two fiscal years toward the goal of constructing a wall on the U.S. border with Mexico. That’s a key point of contention in the ongoing legislative battle over the fate of young people, known as “Dreamers,” who were brought to the country illegally as children.

The proposal also includes $13 billion in new funding to combat the opioid epidemic, which Trump has frequently cited as among his top domestic priorities. The administration would provide a $3 billion boost to the Department of Health and Human Services in the next fiscal year, and $10 billion in 2019.

The proposal takes “money that the Democrats want to put to these social programs and move it to things like infrastructure, move it to things like opioid relief, move it to things that are in line with the president’s priorities so that if it does get spent, at least it get spent to the right places,” Mulvaney said Sunday during an appearance on Fox News Sunday.

Boost for Veterans

Other elements include $85.5 billion in discretionary funding for veterans health services, education, and vocational rehabilitation, the OMB said on Sunday. It is not clear how much of that funding would represent an increase from current spending levels.

The budget also includes $200 billion in federal funds over the next decade that the White House says would spur $1.5 trillion in infrastructure spending through partnerships with state and local governments and private developers. That includes $21 billion over the next two years that the White House says would “jump start key elements of the infrastructure initiative.”

Trump will discuss the public works proposal on Monday with governors, mayors, state legislators and other officials, and he expects to meet with Congressional leaders from both parties at the White House on Feb. 14. The president plans to visit Orlando, Florida, on Feb. 16 for an infrastructure event, and he and cabinet members will also promote the plan at events around the U.S., officials said.

The White House said its initial approach is to offset the $200 billion in the budget for its infrastructure plan with spending cuts elsewhere, including from some transit and transportation programs the administration doesn’t think have been spent effectively. But Trump is open to new sources of funding, a senior White House official told reporters.

‘Robust’ Defense

The White House also didn’t detail how much money it wanted to devote to new spending on the military, but OMB said the proposal would provide “for a robust and rebuilt national defense.” In last year’s budget proposal, Trump called for a $52.3 billion boost for the Defense Department, while asking for deep cuts to the Environmental Protection Agency, State Department, and Department of Health and Human Services.

Mulvaney said this year’s documents — theoretical though they may be — would see those agencies targeted again for budget cuts.

“There’s still going to be the president’s priorities as we seek to spend the money consistently with our priorities, not with the priorities that were reflected most by the Democrats in Congress,” he told Fox News.

Trump on Friday complained on Twitter that in order to boost military spending, “we were forced to increase spending on things we do not like or want.”

The budget proposal assumes that the U.S. economy will ramp up over the next decade to his goal of 3 percent growth, according to an administration official on Friday who confirmed figures to be contained in Monday’s budget proposal. Economic growth is projected at 3.2 percent in 2019 and 2020.

    Read more: http://www.bloomberg.com/news/articles/2018-02-12/trump-to-urge-wall-opioid-spending-as-congress-sets-own-course

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    Cranberries singer Dolores O’Riordan dies

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    Image copyright AFP/Getty Images

    The Cranberries lead singer Dolores O’Riordan has died suddenly at the age of 46, her publicist has confirmed.

    The Irish musician, originally from Limerick, led the band to international success in the 90s with singles including Linger and Zombie.

    A statement from her publicist said: “The lead singer with the Irish band The Cranberries was in London for a short recording session.

    “No further details are available at this time.”

    A Metropolitan Police spokesperson said the police were called to a hotel in Park Lane at 09:05 GMT on Monday, where “a woman in her mid-40s” was pronounced dead at the scene.

    The death is, at this stage, unexplained.

    Her current band mates in The Cranberries – Noel Hogan, Fergal Lawler, and Mike Hogan – paid tribute to the lead singer on social media.

    The message said: “She was an extraordinary talent and we feel very privileged to been part of her life from 1989.”

    Her publicist added: “Family members are devastated to hear the news and have requested privacy at this very difficult time.”

    The Cranberries shot to international fame with their 1993 debut album Everybody Else Is Doing It, So Why Can’t We? and went on to sell over 40 million records worldwide.

    Media playback is unsupported on your device

    Media captionDolores O’Riordan led The Cranberries to international success in the 90s

    In 2017 The Cranberries announced a tour including dates in Europe, the UK, and the US.

    However, in May – shortly into the European tour – the group had to cancel the remainder of the European dates as a result of O’Riordan’s health issues.

    The official Cranberries website cited “medical reasons associated with a back problem” preventing singer Dolores O’Riordan from performing.

    But just before Christmas O’Riordan had posted on Facebook saying she was “feeling good” and had done her “first bit of gigging in months”, leading fans to believe she would soon be performing again.

    O’Riordan tweeted a picture of herself with her cat to fans in early January saying she was “off to Ireland”.

    O’Riordan split from her husband of 20 years, Don Burton in 2014. She and Burton, who is the former tour manager of Duran Duran, have three children together.

    The singer was arrested over an alleged air rage incident in 2014 but was released without charge, after a stewardess was reportedly attacked on a flight from New York to Shannon, County Clare.

    O’Riordan was taken to hospital in Limerick after being questioned by police and later discharged.

    Two years later, O’Riordan was ordered to pay 6,000 euros (£5,300) to charity for headbutting a police officer after an alleged air rage incident.

    She was later diagnosed with bipolar disorder in 2015, which she said explained why she was in a “manic” state on the plane.

    In an interview in 2013 she said that she had been abused as a child, which led to her developing an eating disorder, and eventually she suffered a breakdown.

    She described her family, especially her children, as her “salvation”.

    Irish president Michael D Higgins called her death “a big loss”, and added O’Riordan’s work with The Cranberries “had an immense influence on rock and pop music in Ireland and internationally”.

    Taoiseach (Irish Prime Minister) Leo Varadkar said she was probably “Limerick’s greatest ever rock star”, and that her band “captured all of the angst that came with your teenage years”.

    ‘Unforgettable voice’

    The Kinks guitarist and singer Dave Davies paid tribute to O’Riordan, saying he was “shocked” and that he had seen her “a couple weeks before Christmas”.

    He added “she seemed happy and well”.

    Irish rock band Kodaline were among the first to pay tribute on social media.

    Duran Duran’s official Twitter feed posted a message saying the band was “crushed” to hear of the singer’s death.

    Others to pay tribute include The Late, Late Show presenter, James Corden, who said meeting her when he was 15 years old “made his day”.

    Jim Corr from Irish band The Corrs tweeted offering his “deepest sympathies” to O’Riordan’s family.

    A book of condolence will be opened in her home town of Limerick on Tuesday, at the city council’s headquarters.

    O’Riordan, the youngest of seven children, had written her own songs since she was 12.

    She joined the band while still in her teens, after spotting an advert for a female singer for rock band The Cranberry Saw Us.

    Later changed to The Cranberries, the band’s most successful tracks include Linger (1993), Zombie (1994) – a protest song about bombings that took place in relation to the conflict in Northern Ireland – as well as No Need To Argue (1994) and To the Faithful Departed (1996).

    O’Riordan briefly pursued a solo career after the band split in 2003, before The Cranberries reunited in 2009.


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